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Consequently, with respect to the worsened conditions, which have to be present at that time [21], the delayed therapy initiation (i.e., day 14) was well chosen [23] (note, shorter intervals (day 11 or day 12) after monocrotaline [21,24] may have been premature, and thereby misleading considering the therapeutic effect [21])

Endocrinology , 142(12), 51825189