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[1] [2] However, these studies were limited by small sample sizes, short duration, and lack of long-term safety data

There is no published evidence that longer cycles are dangerous, but there is also no evidence that they are safe

Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, Colina F, Arenas J, Solis-Herruzo JA (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

They respond to treatment more slowly, but with consistent nightly use of Centella Asiatica and Retinol/Bakuchiol, visible improvement in texture and color is achievable in 1012 weeks