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Therapeutic strategies for targeting ferroptosis It has been over a decade since the term ferroptosis was first introduced, and as research has advanced, several clinical drugs and bioactive pharmacological agents have been identified as modulators of ferroptosis, including inhibitors (Table 2) [113,114,115,116,117,118,119,120,121,122,123,124,125] and inducers (Table 3) [126,127,128,129,130,131,132,133,134,135,136,137,138,139,140]
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Oxidative stress is detrimental as free radicals react with vital cellular components, including lipids, proteins, and DNA [8]
While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b
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