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Zhao X, Wu P, Yang Z, Miao RR (2024) Relationship between the efficacy and adverse effects of methotrexate and gene polymorphism

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Key benefits for perimenopausal women: Supports restoration of natural GH pulses that diminish alongside estrogen decline, helping offset fatigue, reduced muscle tone, and metabolic slowdown common in perimenopause Promotes deeper slow-wave sleep by amplifying nighttime GH secretion, addressing the sleep disruption that affects an estimated 40-60% of women during the menopausal transition, per Tyde Wellness Associated with improved body composition including reductions in visceral abdominal fat and increases in lean muscle mass