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Hypoxia at the injury site resolves faster with improved perfusion, removing the oxygen-deficit barrier to fibroblast metabolism

4.2 Level a studies: causal chain closed-loop evidence (ABX FMT rescue/in vivo blocking) 4.2.1 Er miao san (EMS) ABX (Microbiota Dependence/Necessity Signal): The study utilized an antibiotic cocktail (ABX) to deplete or significantly perturb the gut microbiota of recipient mice, testing whether EMS efficacy relies on microbial presence ( FMT (Transferability Test): Following ABX treatment, two types of donor FMTs were administered: from the EMS treatment group and the CIA model group

Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmcher T (2001) Cytokine-associated emotional and cognitive disturbances in humans