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Current Pharmaceutical Design, 2011

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

They stated that there is no strong evidence of possible adverse effects of high vitamin E intake in humans

Assembloids model periportal tissue We next aimed to reconstruct the periportal region of the liver lobule by reproducing the cellular interactions among hepatocytes, cholangiocytes and portal mesenchyme, specifically portal fibroblasts

Besides the formation of GSSG, the simulations revealed GSOH as oxidation product for GSH after H abstraction, and GSOH can be further oxidised to GSO 2 H and GSO 3 H, while the latter might also be produced via intermediate glutathione peroxide formation upon superoxide addition