A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion, which can: Selectively induce apoptosis in senescent cells in vitro and in vivo Neutralize phenotypical and liver chemotoxicity by Doxorubicin Restore fitness, hair density and renal function in fast and naturally aged mice Acknowledgments We thank Felicity Chandler for assistance with IHC experiments, Anne Drabbe and David Brouwer for assistance with in vivo experiments, Yanto Ridwan for assistance with CT and IVIS imaging, Yvette van Loon for genotyping of the mice, Martin Viertler for initial NMR experiments, Boudewijn Burgering for fruitful discussions and Petra de Keizer-Burger for critical reading of the manuscript
It is intended exclusively for in vitro testing and laboratory experiments
Injections allow the body to absorb Vitamin B12 without it having to go through the digestive system like oral tablets
In our study, the inhibited STAT3 activity seems to play more a role in T H 17 cells, since the T H 17 cell response was clearly inhibited
and, therefore, are considered crucial for human health [30]
