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For the sample-specific models per dataset, a drug essentiality score was calculated for each drug by determining the number of samples in which the drug reduced the biomass or the ATP production below the desired threshold for cancer and healthy models, respectively

Changes in renal function may also occur in patients experiencing significant weight loss, as glomerular hyperfiltration associated with obesity improves

In human endothelial cells and animal models, empagliflozin enhances mitochondrial membrane potential, reduces mtROS production, and upregulates antioxidant enzymes (e.g., SOD2, catalase) via AMPK and Nrf2 activation

In formal pharmacokinetic studies in rats following intravenous administration, BPC-157 has a mean elimination half-life of approximately 15.2 minutes, with the peptide becoming undetectable within 4 hours

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