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Homocysteine may inhibit thrombomodulin expression by altering the thiol redox-regulated intracellular transport, and may inhibit thrombomodulin activity by altering the disulfide-bondrich motif inside the protein, protein C activity (Lentz, 1997

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Detailed information of the rabbits was as follows: age ranged from 4 to 5 months, with the actual age deviation controlled within 1 month at the time of administration