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The 500mcg twice daily protocol is aggressive , reserved for significant injuries or the first couple weeks of a severe protocol before dropping to 250mcg

To view a copy of this licence, visit About this article Cite this article Oya, M., Matsuoka, K., Kubota, M

The TB-500 effect follows, with improvements in overall mobility and functional capacity emerging several weeks later

However, they also noted that historic literature often suffers from methodological limitations, such as small sample sizes (averaging ~36 participants) and short study durations

It is often caused by an imbalance of testosterone and estrogen hormones in males