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Collectively, these findings align with broader epidemiological data suggesting that long-term NSW may contribute to BS risk, in part via suppressed immune surveillance mechanisms 11

[22] [23] For example, motexafin gadolinium (MGd) is a new chemotherapeutic agent that selectively targets tumor cells, leading to cell death and apoptosis via inhibition of thioredoxin reductase and ribonucleotide reductase

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The protective effect of melatonin and epithalon on hypothalamic regulation of the reproductive function in female rats in a model of its premature aging and on the estrous cycles of aging animals in different lighting conditions