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AOD9604 is a synthetic hexadecapeptide representing amino acids 176191 of the human growth hormone sequence, with a disulfide bridge between Cys182 and Cys189 that mirrors the structure of the native hGH C-terminal region

When prescribed, it is delivered within a structured, compliance-driven framework designed to prioritize patient safety, regulatory alignment, and clinical oversight

This suggests there is an underlying genetic component of the disease

The bound peptide delivers copper to lysyl oxidase active sites at the collagen crosslinking interface and modulates gene expression in adjacent fibroblasts by altering TGF- and Smad signaling pathways

To obtain the nuclear area, nuclear segmentation was done based on DAPI, followed by quantification of the total nuclear area