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There is a sealing of the barrier with an overexpression of TJ proteins and a de novo organization of junction proteins (203)

In summary, from modulating microglial polarization and neutralizing pro-inflammatory cytokines, to targeting immune checkpoints and astrocyte-derived inhibitory pathways, immunomodulatory strategies offer multifaceted approaches to disrupt the ferroptosisinflammation interplay

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These compounds help increase attention and decrease impulsiveness and hyperactivity in individuals with ADHD