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The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes

Avoid: injectable glutathione these forms carry meaningful safety concerns and should not be used without medical supervision

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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]

The highest second order rate constant k red of 1.4 10 6 M 1 s 1 was determined for the reaction between PfGrx C88S (SH) 2 and roGFP2 C208S (SSG) (Fig