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Renal excretion is minimal, with most of clofazimine and its metabolites eliminated through biliary system

The variants of interest include Cys159Ser (C159S), Cys597Ser (U597S), Cys31Ser (C31S), His571Ala (H571A), and Tyr296Ala (Y296A)

The Bcl-2 family: structures, interactions and targets for drug discovery [J]