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Wilson disease: symptomatic liver therapy

The goal of long-term therapy is maintaining optimal glutathione status to support cellular resilience against ongoing oxidative challenges rather than achieving supraphysiological effects

The reduction in CBF and the diminished vasodilatory response of cerebral vessels to CO 2 , due to the accumulation of A, suggest compromised cerebrovascular reactivity examined by transcranial Doppler and the blood oxygenation level-dependent (BOLD) functional MRI (fMRI) [191,192,193]

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