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The increase in the males could be explained by a higher concentration gradient for the buprenorphine to leave the SC tissues, resulting in a higher-than-predicted C max and AUC 0-t [18]

This occurs because heat increases the kinetic energy and causes the molecules to vibrate so rapidly and violently that the bonds are disrupted

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Once inside the cell, double strand viral RNA can be recognized by RIG-I/MDA5, thus initiating an antiviral response through mitochondrial antiviral signaling (MAVS)

On day 4, 48 h post-transfection, cells were treated with the ferroptosis-inducing compounds erastin, RSL3, or FINO2 in the presence or absence of Ferrostatin-1 (Fer-1) as indicated