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7.3 Development of combined intervention strategies The revised section now discusses the potential of combined therapeutic approaches, such as the co-administration of natural bioactive compounds with probiotics or prebiotics, to synergistically regulate gut microbiota composition, restore intestinal barrier integrity, and reduce hepatic oxidative stress and inflammation

Steady-state concentration, the point where weekly doses produce consistent blood levels, takes approximately 4 weeks of regular dosing

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Its proposed mechanism is potent, selective blockade of the TREK-1 (KCNK2) two-pore-domain potassium channel