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Furthermore, DIM helps shunt estrogen metabolites down a safer pathway by modifying the active cytochrome P450 enzymes

Accumulated cholesterol in late endosomes and lysosomes impairs NPC1mediated trafficking and disrupts acidification, thereby inhibiting autophagic flux and reducing syn degradation [227, 228]

doi: 10.3389/fpsyg.2014.00434 Received 03 March 2014 Accepted 24 April 2014 Published 13 May 2014 Volume 5 - 2014 Edited by Tanya Zilberter, Infotonic Conseil, France Reviewed by Sabine Frank, University of Tbingen, Germany