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With age, oxidative DNA damage increases, leading to excessive PARP-1 activation which depletes NAD+ reserves

*Correspondence: Youcheng Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

elegans: rescue by the DAF-16 and HSF-1 pathways

Through the incorporation of a Drug Affinity Complex (DAC), this modified peptide demonstrates extended signaling persistence within experimental systems, making it a valuable research tool for studying receptor activation over time

(September 2018)