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Cell 122 , 579591 (2005)

The three key axes in ferroptosis defense are: the System Xc /GSH/GPX4 axis, where System Xc imports cystine for GSH synthesis, enabling GPX4 to reduce lipid peroxidation (Chen et al., 2021b)

These findings suggest a microbiome-related approach may improve certain aspects of the condition but underline the complexity of addressing fatigue specifically [44, 78]

In senescent cells, FOXO4 holds p53 in place and stops it from starting apoptosis, which is the process of programmed cell death