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The CTR is also expressed at the cell surface independently of RAMPs and has a distinct phenotype, exhibiting potent responses to human, and other species of CT peptides, but weak responses to amylin

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)