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As cells highly active in the homeostasis of the CNS microenvironment, astrocytes have already been shown to contribute to the pathophysiology of neuroinflammatory and neurodegenerative disorders, such as Alzheimers (85) and Parkinsons diseases (86)

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5 DPP-IV inhibitory activity DPP-IV is a plasma membrane glycoprotein that cleaves N-terminal dipeptides from incretin hormones, such as glucose-dependent insulinotropic peptide (GIP) and glucagon peptide-1 (GLP-1), which are critical for glucose regulation [154]