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Briefly, the patients diagnosis was confirmed by biopsy, stained for amyloid using Congo red [51] and/or 99mTc-DPD, 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy, and TTR mutation status was verified by PCR-based sequencing [52]

These findings demonstrate that ROS exert a direct effect in mediating bronchial responsiveness and asthma

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