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Glutathione levels in cells can indicate overall health

In this regard, a key mode of action to explain this relationship is via glucose transporter type 1 (GLUT1) which increases uptake of the oxidized form of ascorbic acid, dehydroascorbate and subsequently depletes glutathione (Yun et al., 2015)

Although the antioxidant capacity of flavonoids may be compromised after reacting with ROS, recent studies have shown that the oxidized derivatives of certain flavonoids can significantly enhance their original antioxidant properties by activating the NRF2/KEAP1 pathway and upregulating the cell's endogenous antioxidant capacity [423]

[Abstract]2024 Dec 31:111368

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