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F.LoiblS.MunsterP.BruzzoneM.et al (2018)

Osoby z nadwraliwoci na mied lub inne skadniki preparatu mog dowiadczy reakcji alergicznych, objawiajcych si zaczerwienieniem, swdzeniem lub wysypk

For researchers using oral capsules, taking the compound 30 to 60 minutes before meals in a fasted state may enhance fat oxidation effects, though this recommendation is based on theoretical considerations rather than controlled studies

However, the most significant difference is between systemic circulation (minutes) and topical application on the skin (hours of local residence time)