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There is also evidence that peripheral inflammation driven by gut dysbiosis can reduce expression of key protein degradation systems in the brain (such as ubiquitinproteasome pathway and autophagy genes), thereby accelerating the accumulation of toxic proteins [101]

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CRF, Case Report Form

Unfortunately, the levels of this antioxidant will be reduced due to several causes, such as aging, a healthy diet and a sedentary lifestyle

Images were captured using a BioRad Radiance 3-channel confocal microsope and 3D image stacks created for analysis in Volocity (Improvision Inc., Lexington MA)