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Common research applications include single-receptor pharmacology (semaglutide and liraglutide as GLP-1 reference agonists), dual-receptor comparison studies (tirzepatide for GIP/GLP-1, mazdutide and survodutide for GLP-1/glucagon), triple-receptor research (retatrutide), and multi-pathway combinations using amylin agonists alongside incretin agonists (cagri-sema, retatrutide+cagrilintide)

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Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks