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The activation of these pathways can also induce the production of growth factors, such as TGF-beta and IGF-1, which promote fibroblast proliferation and collagen synthesis, enhancing the strength and repair capacity of the ligament

Acknowledgements We thank Prof

Oxidative stressors are shutting down the blood vessels preventing proper amounts of oxygen from getting to the mitochondria

Glutathione depletion is an active research model in cell biology, with studies using GSH-depleting agents (such as buthionine sulfoximine or diethyl maleate) to examine the cellular consequences of oxidative stress

Discectomy Surgical removal of all or part of an intervertebral disc