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Recent investigations further indicated that UA may operate as a protective factor mediated through astroglia for dopaminergic neurons from glutamate toxicity ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )

Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed

Too much vitamin B1 (thiamine) might raise it (hypertension), while too much vitamin B2 (riboflavin) might lower it (hypotension)

Vitamin deficiencies