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Endothelial injury, an intriguing effect of methotrexate and cyclophosphamide during hematopoietic stem cell transplantation in mice

have reported in healthy male smokers ( n = 21) compared to non-smokers ( n = 21) a significant increase in externalization of PS to the outer leaflet of the RBCs membrane, a hallmark of eryptosis, which was significantly correlated to the plasma level of CRP and GSH concentration in erythrocytes [440]

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It functions as the primary intracellular antioxidant, donating electrons to neutralise reactive oxygen species (ROS) produced during mitochondrial respiration and inflammatory processes

2016;11(5):e155289