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For example, human induced pluripotent stem cell (iPS cell) astrocyte studies indicate that PSEN1 mutations enhance cytokine signaling via disrupted intramembrane proteolysis, lowering the threshold for astrocyte reactivity and predisposing cells to exaggerated inflammatory responses to modest stimuli 79

In a study carried out in vitro, pioglitazone stimulated apo A-I secretion in HepG2 cells (Qin et al., 2007)

Low concentrations of ascorbate, glutathione, and superoxide dismutase are the most prevalent antioxidant deficits during the pathogenic process of diabetes

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