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If this happens, try cutting your dose in half for the first week to let your system acclimate

-Glutamylcyclotransferase (GGCT) is a key enzyme catalyzing 5-oxoproline formation in the - glutamyl cycle

[DOI] [PubMed] [Google Scholar] 10.Newcorn J.H., Halperin J.M., Jensen P.S., Abikoff H.B., Arnold L.E., Cantwell D.P., Conners C.K., Elliott G.R., Epstein J.N., Greenhill L.L., et al

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For therapeutic uses of drugs that can cause hypersensitivity reactions, the risk of hypersensitivity development is often weighted against the therapeutic benefit of the drug, given that subsequent accidental or unintentional exposure to the same molecule would be unlikely