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whether these radical-trapping antioxidant pathways compensate for GPX4 downregulation in affected kidneys or if their dysfunction exacerbates ferroptosis susceptibility remains unknown, limiting multi-targeted therapeutic design

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Thus, inventors of the present invention have now successfully developed transdermal gel compositions that can be applied in the form of a transdermal patch to deliver GHK-Cu in sufficient amounts over at least 12 hrs and preferably over 24 hrs

RNA concentration was measured using NanoDrop 2000 and RNA integrity was assessed by agilent Bioanalyzer 2100