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329 Lactylation in metabolic disorders Lactylation, as one of the novel PTMs derived from metabolism, interacts with various metabolic pathways and plays an important role in the occurrence and development of metabolic diseases, such as diet-induced obesity, fatty liver disease, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), and osteoporosis (Figs

In addition, Tirzepatide also binds to GIP receptors on -cells to co-stimulate insulin secretion by upregulating intracellular cAMP levels via GPCR-signaling

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Wierenga LM, Ruigrok A, Aksnes ER, Barth C, Beck D, Burke S, et al