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Patients with Candida overgrowth frequently present with functional deficiencies of these neurotransmitters despite an apparently adequate diet

However, when zinc levels are adequate, the mRNA of ZIP4 becomes unstable, and the protein is internalized and quickly degraded

Interestingly, a small trial in 30 premenopausal women found that daily multivitamin supplementation for ten weeks did not improve overall mood, but when the supplement also contained 7 mg/day of zinc (RDA=8 mg/day), the authors noted significant improvements in two components of POMS: the anger-hostility and the depression-dejection scores (140)

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Biochimica et Biophysica Acta, 1822 (5), 625