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10.3892/mmr.2014.2292 170 WuX.LiY.ZhangS.ZhouX

ERK1/2 functions to enhance mitogenic signals in cells and can be activated by elevated intracellular calcium (from PLC/PKC events), and indirectly via PKA, both of which as outlined are stimulated by GH and IGF activity (106, 124)

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Researchers should evaluate IGF-1 LR3 with an understanding that test method, reference standards, peak interpretation, oxidation/deamidation behavior, and compound complexity can all affect reported purity values