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Baicalein and kaempferol have been demonstrated to alleviate demyelination and microglial activation caused by cuprizone poisoning by inhibiting the STAT3 and NF-B signaling pathways (259)

It enhances the antioxidant defense system by raising the activity of enzymes such as SOD, POD, and CAT, as well as non-enzymatic antioxidants like phenolics and flavonoids, which minimize oxidative damage produced by ROS (Figure 4)

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