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Keywords Liver disease, Gutliver axis, Gut microbial dysbiosis, Microbial metabolites, Gut barrier, Ecological niche remodeling, Therapeutics, Multi-omics Introduction Liver diseases are one of the leading causes of death and disability worldwide, with a broad spectrum ranging from metabolic dysfunctionassociated steatotic liver disease (MASLD)/nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and viral hepatitis to cirrhosis and hepatocellular carcinoma (HCC)

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Trends Biochem Sci 39(4):191198 Ashtari S, Pourhoseingholi MA, Rostami K, Aghdaei HA, Rostami-Nejad M, Busani L, Tavirani MR, Zali MR (2019) Prevalence of gluten-related disorders in asia-pacific region: a systematic review