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10c), and small bacteria with an apparent teardrop-shape (Fig

These coumarins inhibit NF-B activation, reducing expression of pro-inflammatory cytokines (TNF-, IL-6, IL-1), central mediators of synovial inflammation and cartilage destruction in RA (35), while their antioxidant properties scavenge ROS, enhance GSH levels, and reduce MDA, mitigating oxidative stress-induced damage (69)

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Conversely, fecal microbiota transplantation from stressed mice can alter neurotransmitter profiles in recipients via vagal activation (Siopi et al., 2023)