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The NO pathway plays an important role in intestinal smooth muscle function and mucosal protection, and disruption of this system is associated with certain inflammatory bowel presentations

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This modulation decreases the metabolism of the cardiovascular risk factor phenylalanine, ultimately reducing myocardial collagen deposition, lowering the cardiac weight index, slowing the progression of myocardial fiber thickening and necrosis, and preventing and ameliorating ISO-induced myocardial fibrosis ( 3.3 Antagonism targeting ion channel disorders Oxidative stress and inflammatory processes accelerate the development of atrial fibrosis, leading to increased collagen deposition and structural remodeling of the atria

Biomaterials 109, 5568

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