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Glutathione An antioxidant that protects against environmental stress and promotes a brighter complexion

In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

Plates were incubated at room temperature for 30-60 min in the dark, and fluorescence was read at Ex/Em = 490/520 nm

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Reduced BDNF availability may in turn limit TrkB phosphorylation and attenuate downstream PI3K/Akt and MAPK/ERK signaling (Numakawa and Kajihara, 2023)