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A central mechanism often implicated is the dysfunction of Electron Transport Chain (ETC), which plays a crucial role in ATP production

As this pathway is absent in humans and in human commensal bacteria MTAN is a promising candidate as a target for new drugs

Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration

Understanding Protein Haptenation Simple Reactivity In its simplest form, protein haptenation results in a single (electrophilic) molecule covalently attached to a side chain of a single (nucleophilic) amino acid in a protein, typically Cys, Lys, His, Arg, and Tyr (Figure 1)