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Precauciones: pese a esta aparente inocuidad aguda, la falta de investigaciones amplias deja interrogantes

10.1080/15287394.2011.567950 11 ChenJ

This family of proteins can activate or inhibit a variety of target genes, such as p27kip1 and cyclin D (CCND) CYR61, which regulate the cell cycle, the bim and fasL genes that mediate apoptosis [40], TNF and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) [41], and the RAD51 gene involved in DNA damage repair

Rats pretreated with the traditional liver tonics Andrographis paniculata (100-200 mg/kg/day) and Picrorhiza kurroa (50-100 mg/kg/day) had lower markers of liver damage (ALT, AST, lipid peroxidation) after acetaminophen intoxication (Nagalekshmi 2011