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Int J Mol Sci 2020, 21:8113
doi: 10.1038/s41585-018-0003-3 3 ChoyJTEisenbergML
Experimental work has associated Epithalon with modulation of genes such as: CD5 linked to immune cell differentiation and adaptive immune responses IL-2 involved in T-cell regulation and broader white blood cell signaling MMP2 associated with extracellular matrix remodeling, collagen dynamics, and tissue repair Tram1 related to protein processing and transport Arylalkylamine-N-acetyltransferase (AANAT) a key enzyme in melatonin synthesis pCREB-related targets transcription factors involved in circadian signaling and potentially anti-neoplastic pathways Telomerase-associated components consistent with observations on telomere biology These gene-level interactions position Epithalon as a useful tool compound for studying how small peptides might influence transcriptional regulation in immune, connective, circadian, and genomic-maintenance pathways
d 5 -JA was added to the extraction solvent (isopropanol: formic acid at 99.5: 0.5, v/v) as internal standard
doi:10.1002/jimd.12593
