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Cholesterol metabolism is deregulated in tumors, which exhibit a paradoxical stimulation in de novo cholesterol synthesis despite hypoxia-mediated downregulation of HMG-CoA reductase by hypoxia ( Figure 4 )

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References 1.Seiwerth S., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., Drmic D., Stupnisek M., Misic M., Vuletic L.B., et al

New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response