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This stimulatory effect occurs through multiple mechanisms, including increased COL1A1 and COL1A2 gene transcription, enhanced procollagen mRNA stability, and improved post-translational processing of procollagen molecules

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The study found that the exosomal SP94-Lamp2bRRM, which targets HCC, aids in delivering small interfering RNA to improve sorafenib-induced ferroptosis by inhibiting the expression of GPX4 and DHODH