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c) The trial involves a drug, biological, or device product that is manufactured in the United States or its territories and is exported for research. 4 See 5 See 6 See 7 See 8 It also referenced other policy documents, including the 1993 International Conference on Harmonization (ICH) guideline, which advised against arbitrary upper-age cutoffs in clinical trials that may result in underrepresentation of older adults

2012 Jun 1;71(11):956-61

High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease

The potential to treat lung cancer via inhalation of repurposed drugs

Disruptions in mitochondrial activity can lead to increased oxidative stress, contributing to neurodegenerative conditions such as Alzheimers and Parkinsons diseases