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Unlike the SmTGR U597C variant for which the flavin is observed to begin reoxidizing at 0.1 s in the presence of limiting NADPH concentration (Smith et al., 2023), this variant maintains the partially reduced flavin and thiolate-FAD charge transfer state

The measured position is that the pathway is important and GHK-Cu is pleiotropic, so overlap is likely but a clean, primary demonstration that GHK-Cu drives Wnt-dependent anagen in human follicles is not something the record firmly establishes

These principles can be reasonably extended to agar-based systems through appropriate surface engineering strategies

Zhu et al., 2021)