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Sulfation (30-35%) - SAFE Safe elimination pathway DECREASES by 33% during pregnancy Limited capacityeasily saturated with higher or repeated doses Predominant pathway in fetuses/children but quickly overwhelmed 3

doi: 10.1016/j.scitotenv.2021.152344 198 SahaA.MakwanaC.ManivelP

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Investigations have revealed that the orphan nuclear receptor NR4A1 is pivotal in mediating metformins protective effects against endothelial dysfunction induced by high glucose levels

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